Polygenic risk and causal inference of psychiatric comorbidity in inflammatory bowel disease among patients with European ancestry.

Yao LiCharles N BernsteinWei XuPingzhao Hu

Published in: Journal of translational medicine (2022)

PC status in IBD depends on genetic influences among persons with European ancestry. The PRS could potentially be applied to PC risk screening to identify persons with IBD at a high risk of PC. Around 13% of this genetic influence could be explained by the expression level of the RBPMS gene.

Keyphrases

genome wide
copy number
poor prognosis
mental health
ulcerative colitis
binding protein
long non coding rna
genome wide identification