Mapping the complexity and diversity of tertiary lymphoid structures in primary and peritoneal metastatic gastric cancer.
Tessa S Groen-van SchootenRosalia Franco FernandezNicole C T van GriekenEmma N BosJens SeidelJob SarisCarolina Martínez-CiarpagliniTania C FleitasDaniela S ThommenTanja D de GruijlJoep GrootjansSarah DerksPublished in: Journal for immunotherapy of cancer (2024)
The observation that GC-derived peritoneal metastases often contain immature TLS which are associated with immune suppressive regulatory tumor-infiltrating leucocytes, is in keeping with the lack of response to immune checkpoint blockade and the poor prognostic features of peritoneal metastatic GC, which needs to be taken into account when optimizing immunomodulatory strategies for metastatic GC.