Genome-wide association meta-analysis of age at first cannabis use.
Camelia C MinicăKarin J H VerweijPeter J van der MostHamdi MbarekManon BernardKristel R van EijkPenelope A LindMeng Zhen LiuDominique F MaciejewskiTeemu PalviainenCristina Sánchez-MoraRichard ShervaMichelle TaylorRaymond K WaltersAbdel AbdellaouiTimothy B BigdeliSusan J T BranjeSandra A BrownMiguel CasasRobin P CorleyGeorge Davey-SmithGareth E DaviesErik A EhliLindsay FarrerIryna O FedkoIris Garcia-MartínezScott D GordonCatharina A HartmanAndrew C HeathIan B HickieMatthew HickmanChristian J HopferJouke Jan HottengaRené S KahnJaakko A KaprioTellervo KorhonenHenry R KranzlerKen KrauterPol A C van LierPamela A F MaddenSarah E MedlandMichael C NealeWim H J MeeusGrant W MontgomeryIlja M NolteAlbertine J OldehinkelZdenka PausovaJosep A Ramos-QuirogaVanesa RicharteRichard J RoseJean ShinMichael C StallingsTamara L WallJennifer J WareMargaret J WrightHongyu ZhaoHans M KootTomas PausJohn K HewittMarta RibasésAnu LoukolaMarco P BoksHarold SniederMarcus R MunafoJoel GelernterDorret I BoomsmaNicholas G MartinNathan A GillespieJacqueline M VinkEske M DerksPublished in: Addiction (Abingdon, England) (2018)
Age at cannabis initiation appears to be moderately heritable in western countries, and individual differences in onset can be explained by separate but correlated genetic liabilities. The significant association between age of initiation and ATP2C2 is consistent with the role of calcium signalling mechanisms in substance use disorders.