Long non-coding RNAs in regulation of adipogenesis and adipose tissue function.
Tiziana SquillaroGianfranco PelusoUmberto GalderisiGiovanni Di BernardoPublished in: eLife (2020)
Complex interaction between genetics, epigenetics, environment, and nutrition affect the physiological activities of adipose tissues and their dysfunctions, which lead to several metabolic diseases including obesity or type 2 diabetes. Here, adipogenesis appears to be a process characterized by an intricate network that involves many transcription factors and long noncoding RNAs (lncRNAs) that regulate gene expression. LncRNAs are being investigated to determine their contribution to adipose tissue development and function. LncRNAs possess multiple cellular functions, and they regulate chromatin remodeling, along with transcriptional and post-transcriptional events; in this way, they affect gene expression. New investigations have demonstrated the pivotal role of these molecules in modulating white and brown/beige adipogenic tissue development and activity. This review aims to provide an update on the role of lncRNAs in adipogenesis and adipose tissue function to promote identification of new drug targets for treating obesity and related metabolic diseases.
Keyphrases
- gene expression
- adipose tissue
- insulin resistance
- high fat diet induced
- type diabetes
- transcription factor
- long non coding rna
- high fat diet
- genome wide identification
- metabolic syndrome
- network analysis
- dna methylation
- weight loss
- skeletal muscle
- poor prognosis
- glycemic control
- weight gain
- emergency department
- physical activity
- cardiovascular disease
- oxidative stress
- body mass index
- atomic force microscopy
- adverse drug
- single molecule