From secondary to tertiary mitral regurgitation: the paradigm shifts, but uncertainties remain.
Antonio LandiFrancesco Fulvio FaletraAnna Giulia PavonGiovanni PedrazziniMarco ValgimigliPublished in: European heart journal. Cardiovascular Imaging (2021)
Secondary mitral regurgitation (MR) is the most common and undertreated form of MR, whose contribution to poor prognosis and indications to correction remains under discussion. MR has been characterized into 'proportionate' or 'disproportionate', based on left ventricle (LV) and regurgitant volumes, whereas 'tertiary' MR identifies conditions, in which regurgitation is pathologic per se and actively contributes to LV dysfunction. Echocardiographic and anatomo-pathological studies revealed that secondary MR prompts subtle leaflet maladaptive changes, actively contributing to the dynamic progression of secondary MR. We critically discuss the paradigm shift from secondary to tertiary MR and question the notion that MV leaflets play a passive role in secondary MR. We also review the role of standard transthoracic echocardiography for appraising and quantifying maladaptive MV leaflet changes and LV volumes and call for a more sophisticated and comprehensive imaging framework for classifying MR in future interventional studies.
Keyphrases
- contrast enhanced
- magnetic resonance
- poor prognosis
- mitral valve
- magnetic resonance imaging
- computed tomography
- left ventricular
- pulmonary hypertension
- long non coding rna
- radiation therapy
- neoadjuvant chemotherapy
- genome wide
- photodynamic therapy
- mass spectrometry
- coronary artery
- pulmonary arterial hypertension
- aortic stenosis