Attenuation of aquaporin-3 and epidermal growth factor receptor expression and activation in systemic sclerosis dermal fibroblasts.

Elham FarhadiMahdi MahmoudiFarzaneh RahmaniBahman YousefiAbdolfattah SarafnejadHoda KavosiElham KarimizadehAhmadreza JamshidiFarhad Gharibdoost

Published in: Journal of cellular physiology (2018)

Downregulation of AQP3 expression in SSc fibroblasts may be related to reduced EGFR expression and activation. TGF-β1 (alone or in combination with EGF) only can upregulate AQP3 expression in SSc fibroblasts so, TGF-β1 affect MMP-1 and MMP-9 just in SSc fibroblasts.

Keyphrases

epidermal growth factor receptor
poor prognosis
systemic sclerosis
tyrosine kinase
extracellular matrix
small cell lung cancer
binding protein
interstitial lung disease
signaling pathway
rheumatoid arthritis