One-Pot Synthesis of Enantiopure Pyrrolopiperazines.
Pablo PertejoBeatriz González-SaizRoberto QuesadaMaría García-ValverdePublished in: The Journal of organic chemistry (2020)
A simple one-pot protocol for the synthesis of fused pyrrolopiperazines with a complete diastereoselectivity has been developed. This novel methodology combined the Ugi reaction with a spontaneous enamine alkylation on a multicomponent domino reaction, starting from nonprotected diamines and arylglyoxals.