Potential of Gene and Cell Therapy for Inner Ear Hair Cells.
Min Young LeeYong Ho ParkPublished in: BioMed research international (2018)
Sensorineural hearing loss is caused by the loss of sensory hair cells (HCs) or a damaged afferent nerve pathway to the auditory cortex. The most common option for the treatment of sensorineural hearing loss is hearing rehabilitation using hearing devices. Various kinds of hearing devices are available but, despite recent advancements, their perceived sound quality does not mimic that of the "naïve" cochlea. Damage to crucial cochlear structures is mostly irreversible and results in permanent hearing loss. Cochlear HC regeneration has long been an important goal in the field of hearing research. However, it remains challenging because, thus far, no medical treatment has successfully regenerated cochlear HCs. Recent advances in genetic modulation and developmental techniques have led to novel approaches to generating HCs or protecting against HC loss, to preserve hearing. In this review, we present and review the current status of two different approaches to restoring or protecting hearing, gene therapy, including the newly introduced CRISPR/Cas9 genome editing, and stem cell therapy, and suggest the future direction.
Keyphrases
- hearing loss
- cell therapy
- crispr cas
- genome editing
- induced apoptosis
- stem cells
- current status
- gene therapy
- mesenchymal stem cells
- cell cycle arrest
- oxidative stress
- healthcare
- endoplasmic reticulum stress
- genome wide
- risk assessment
- cell death
- gene expression
- physical activity
- signaling pathway
- climate change
- combination therapy
- replacement therapy
- pi k akt
- cell proliferation
- bone marrow
- mass spectrometry