Longitudinal course of neurofilament light chain levels in amyotrophic lateral sclerosis-insights from a completed randomized controlled trial with rasagiline.
Simon WitzelJeffrey M StatlandPetra SteinackerMarkus OttoJohannes DorstJoachim SchusterRichard J BarohnAlbert C LudolphPublished in: European journal of neurology (2023)
Post hoc NfL measurements in completed clinical trials are helpful in interpreting NfL data from ongoing and future interventional trials and could provide hypothesis-generating complementary insights. Further studies are warranted to ultimately differentiate NfL response to treatment from other factors.