Safety, pharmacokinetics, metabolism and radiation dosimetry of 18F-tetrafluoroborate (18F-TFB) in healthy human subjects.

Huailei JiangNicholas R SchmitAlex R KoenenAditya BansalMukesh K PandeyRobert B GlynnBradley J KempKera L DelaneyAngela DispenzieriJamie N Bakkum-GamezKah-Whye PengStephen J RussellTina M GundersonVal J LoweTimothy R DeGrado

Published in: EJNMMI research (2017)

This initial study in healthy human subjects showed 18F-TFB was safe and distributed in the human body similar to other iodide analogs. These data support further translational studies with 18F-TFB as NIS gene reporter and imaging biomarker for thyroid cancer and other disease processes that import iodide.

Keyphrases

endothelial cells
pluripotent stem cells
high resolution
gene expression
genome wide
electronic health record
molecular docking
transcription factor
deep learning
fluorescence imaging
genome wide identification