Omics and Extreme Phenotyping Reveal Longitudinal Association Between Left Atrial Size and Pulmonary Vascular Resistance in Group 2 Pulmonary Hypertension.
Neil J KellyDavid NewhouseHimal ChapagainAshish PatelYicheng TangAto HowardAnna KirillovaHee-Jung J KimHaris RahmanWadih El KhourySeyed Mehdi NouraieGavin W HickeyLeyla Elif SadeSandeep K JainStephen Y ChanPublished in: Journal of the American Heart Association (2023)
Guided by pharmacomic and phenomic screens in a rigorously phenotyped cohort, we identify a longitudinal association between left atrial diameter indexed to body surface area and pulmonary vascular resistance with implications for the future development of diagnostic, prognostic, and therapeutic tools.