The roles of TNFAIP2 in cancers and infectious diseases.
Lin JiaYundong ShiYi WenWei LiJing FengCeshi ChenPublished in: Journal of cellular and molecular medicine (2018)
TNFα-induced protein 2 (TNFAIP2) is a primary response gene of TNFα. TNFAIP2 is highly expressed in immune cells and the urinary bladder. The expression of TNFAIP2 is regulated by multiple transcription factors and signalling pathways, including NF-κB, KLF5 and retinoic acid. Physiologically, TNFAIP2 appears to be a multiple functional mediator not only for inflammation, angiogenesis and tunneling nanotube (TNT) formation but also as a regulator of cell proliferation and migration. The expression of TNFAIP2 is frequently abnormal in human cancers and in infectious diseases. Due to its significant functions in cell proliferation, angiogenesis, migration and invasion, TNFAIP2 could be a potential diagnostic biomarker and therapeutic target for cancer.
Keyphrases
- infectious diseases
- endothelial cells
- transcription factor
- poor prognosis
- cell proliferation
- rheumatoid arthritis
- oxidative stress
- high glucose
- binding protein
- stem cells
- vascular endothelial growth factor
- squamous cell carcinoma
- pi k akt
- genome wide
- gene expression
- cell therapy
- immune response
- single cell
- copy number
- papillary thyroid
- dna methylation
- human health
- toll like receptor
- induced pluripotent stem cells
- squamous cell