Effect of 95% Ethanol Khat Extract and Cathinone on in vitro Human Recombinant Cytochrome P450 (CYP) 2C9, CYP2D6, and CYP3A4 Activity.

Sharoen Yu Ming LimAthira Rafhana Binti AzidinYee Tze UngMustafa Al-ShaggaMohammed Abdullah AlshawshZahurin MohamedChin Eng OngYan Pan

Published in: European journal of drug metabolism and pharmacokinetics (2019)

Khat-drug interactions are possible due to administration of clinical drugs metabolized by CYP2C9/CYP2D6/CYP3A4 together with khat chewing. Further in vivo studies are required to confirm our findings and identify the causative constituents of these inhibitory effects.

Keyphrases

endothelial cells
oxidative stress
induced pluripotent stem cells
pluripotent stem cells
case control
essential oil