Combining factorial and multi-arm multi-stage platform designs to evaluate multiple interventions efficiently.
Ian R WhiteBabak Choodari-OskooeiMatthew Robert SydesBrennan C KahanLeanne McCabeAnna TurkovaHanif EsmailDiana M GibbDeborah FordPublished in: Clinical trials (London, England) (2022)
A combined factorial-MAMS design can combine the efficiencies of factorial trials and multi-arm multi-stage platform trials. It allows us to address multiple research questions under one protocol and to test multiple new treatment options, which is particularly important when facing a new emergent infection such as COVID-19.