Delineating a role for methionine metabolism in colorectal cancer.
Shiyu LiuJason W LocasalePublished in: Cancer research (2023)
Advances in mass spectrometry allow for broader applications of metabolomics in research and clinical applications. In a recent issue of Nature Metabolism, Voorde and colleagues utilized metabolite profiling to investigate the metabolism of colorectal cancer (CRC) in mouse models, organoids and patients. This study underscores the utility of metabolomics in distinguishing CRC, offering potential for its use in precision medicine. It also revealed a pivotal role for adenosylhomocysteinase in the methionine cycle and highlighted its potential as a therapeutic target.
Keyphrases
- mass spectrometry
- end stage renal disease
- liquid chromatography
- newly diagnosed
- ejection fraction
- single cell
- chronic kidney disease
- mouse model
- prognostic factors
- peritoneal dialysis
- amino acid
- gas chromatography
- patient reported outcomes
- risk assessment
- human health
- climate change
- ms ms
- solid phase extraction
- genome wide analysis