Jason W Locasale

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2014-2024
Publications (10 Years): 71

Top Venues

Nature communications

Nature metabolism

Cancer research

Nature immunology

Duke University School of Medicine

Massachusetts Institute of Technology (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Duke University School of Medicine Aug 01 2015

United States

Associate Professor :: Pharmacology and Cancer Biology

Cornell University - Jul 31 2015

United States

Assistant Professor

Harvard Medical School

United States

Postdoc :: Medicine/Systems Biology

Education History

Massachusetts Institute of Technology

United States

PHD

Publications

Fangchao Wei, Shiyu Liu, Juan Liu, Yudong Sun, Annamarie E Allen, Michael A Reid, Jason W Locasale
Separation of reproductive decline from lifespan extension during methionine restriction. Nature aging (2024)
Yudong Sun, Jason W Locasale
Histone butyrylation is a dietary link to epigenetics. Nature metabolism 6 (4) (2024)
Andrew J Monteith, Haley E Ramsey, Alexander James Silver, Donovan J Brown, Dalton L Greenwood, Brianna N Smith, Ashley D Wise, Juan Liu, Sarah D Olmstead, Jackson Watke, Maria P Arrate, Agnieszka E Gorska, Londa Fuller, Jason W Locasale, Matthew C Stubbs, Jeffrey C Rathmell, Michael R Savona
Lactate Utilization Enables Metabolic Escape to Confer Resistance to BET Inhibition in Acute Myeloid Leukemia. Cancer research 84 (7) (2024)
Ran Zhang, Jingqi Fang, Xueshu Xie, Chris Carrico, Jesse G Meyer, Lei Wei, Joanna Bons, Jacob Rose, Rebeccah Riley, Ryan Kwok, Prasanna Vadhana Ashok Kumaar, Yini Zhang, Wenjuan He, Yuya Nishida, Xiaojing Liu, Jason W Locasale, Birgit Schilling, Eric Verdin
Regulation of urea cycle by reversible high-stoichiometry lysine succinylation. Nature metabolism 6 (3) (2024)
Ran Zhang, Jingqi Fang, Xueshu Xie, Chris Carrico, Jesse G Meyer, Lei Wei, Joanna Bons, Jacob Rose, Rebeccah Riley, Ryan Kwok, Prasanna Vadhana Ashok Kumaar, Yini Zhang, Wenjuan He, Yuya Nishida, Xiaojing Liu, Jason W Locasale, Birgit Schilling, Eric Verdin
Regulation of urea cycle by reversible high-stoichiometry lysine succinylation. Nature metabolism 6 (3) (2024)
Andrew J Monteith, Haley E Ramsey, Alexander James Silver, Donovan J Brown, Dalton L Greenwood, Brianna N Smith, Ashley D Wise, Juan Liu, Sarah D Olmstead, Jackson Watke, Maria P Arrate, Agnieszka E Gorska, Londa Fuller, Jason W Locasale, Matthew C Stubbs, Jeffrey C Rathmell, Michael R Savona
Lactate Utilization Enables Metabolic Escape to Confer Resistance to BET Inhibition in Acute Myeloid Leukemia. Cancer research 84 (7) (2024)
Jason W Locasale, Marcus DaSilva Goncalves, Maira Di Tano, Guillermo Burgos-Barragan
Diet and Cancer Metabolism. Cold Spring Harbor perspectives in medicine (2024)
Shiyu Liu, Xiaojing Liu, Jason W Locasale
Quantification of metabolic activity from isotope tracing data using automated methodology. bioRxiv : the preprint server for biology (2024)
Shiyu Liu, Xiaojing Liu, Jason W Locasale
Quantification of metabolic activity from isotope tracing data using automated methodology. bioRxiv : the preprint server for biology (2024)
Yudong Sun, Jason W Locasale
Histone butyrylation is a dietary link to epigenetics. Nature metabolism (2024)
Andrew J Monteith, Haley E Ramsey, Alexander James Silver, Donovan J Brown, Dalton L Greenwood, Brianna N Smith, Ashley D Wise, Juan Liu, Sarah D Olmstead, Jackson Watke, Maria P Arrate, Agnieszka E Gorska, Londa Fuller, Jason W Locasale, Matthew C Stubbs, Jeffrey C Rathmell, Michael R Savona
Lactate utilization enables metabolic escape to confer resistance to BET inhibition in acute myeloid leukemia. Cancer research (2024)
Shiyu Liu, Xiaojing Liu, Jason W Locasale
Quantification of metabolic activity from isotope tracing data using automated methodology. bioRxiv : the preprint server for biology (2024)
Ran Zhang, Jingqi Fang, Xueshu Xie, Chris Carrico, Jesse G Meyer, Lei Wei, Joanna Bons, Jacob Rose, Rebeccah Riley, Ryan Kwok, Prasanna Vadhana Ashok Kumaar, Yini Zhang, Wenjuan He, Yuya Nishida, Xiaojing Liu, Jason W Locasale, Birgit Schilling, Eric Verdin
Regulation of urea cycle by reversible high-stoichiometry lysine succinylation. Nature metabolism (2024)
Yudong Sun, Jason W Locasale
Histone butyrylation is a dietary link to epigenetics. Nature metabolism 6 (4) (2024)
Andrew J Monteith, Haley E Ramsey, Alexander James Silver, Donovan J Brown, Dalton L Greenwood, Brianna N Smith, Ashley D Wise, Juan Liu, Sarah D Olmstead, Jackson Watke, Maria P Arrate, Agnieszka E Gorska, Londa Fuller, Jason W Locasale, Matthew C Stubbs, Jeffrey C Rathmell, Michael R Savona
Lactate Utilization Enables Metabolic Escape to Confer Resistance to BET Inhibition in Acute Myeloid Leukemia. Cancer research 84 (7) (2024)
Fangchao Wei, Shiyu Liu, Juan Liu, Yudong Sun, Annamarie E Allen, Michael A Reid, Jason W Locasale
Separation of reproductive decline from lifespan extension during methionine restriction. Nature aging 4 (8) (2024)
Andrew J Monteith, Haley E Ramsey, Alexander James Silver, Donovan J Brown, Dalton L Greenwood, Brianna N Smith, Ashley D Wise, Juan Liu, Sarah D Olmstead, Jackson Watke, Maria P Arrate, Agnieszka E Gorska, Londa Fuller, Jason W Locasale, Matthew C Stubbs, Jeffrey C Rathmell, Michael R Savona
Lactate Utilization Enables Metabolic Escape to Confer Resistance to BET Inhibition in Acute Myeloid Leukemia. Cancer research 84 (7) (2024)
Fangchao Wei, Jason W Locasale
Lysine metabolism at the nexus of crotonylation and tumor immunity. Cell research (2023)
Chunbo He, Dezhen Wang, Surendra K Shukla, Tuo Hu, Ravi Thakur, Xiao Fu, Ryan J King, Sai Sundeep Kollala, Kuldeep S Attri, Divya Murthy, Nina V Chaika, Yuki Fujii, Daisy Gonzalez, Camila G Pacheco, Yudong Qiu, Pankaj K Singh, Jason W Locasale, Kamiya Mehla
Vitamin B6 competition in the tumor microenvironment hampers antitumor functions of NK cells. Cancer discovery (2023)
Yudong Sun, Vijyendra Ramesh, Fangchao Wei, Jason W Locasale
Methionine availability influences essential H3K36me3 dynamics during cell differentiation. bioRxiv : the preprint server for biology (2023)
Shiyu Liu, Jason W Locasale
Delineating a role for methionine metabolism in colorectal cancer. Cancer research (2023)
Ziwei Dai, Weiyan Zheng, Jason W Locasale
Amino acid variability, tradeoffs and optimality in human diet. Nature communications 13 (1) (2022)
Christos Karampelias, Kathleen Watt, Charlotte L Mattsson, Ángel Fernández Ruiz, Habib Rezanejad, Jiarui Mi, Xiaojing Liu, Lianhe Chu, Jason W Locasale, Gregory S Korbutt, Meritxell Rovira, Ola Larsson, Olov Andersson
MNK2 deficiency potentiates β-cell regeneration via translational regulation. Nature chemical biology 18 (9) (2022)
Xin Gu, Patrick Jouandin, Pranav V Lalgudi, Rich Binari, Max L Valenstein, Michael A Reid, Annamarie E Allen, Nolan Kamitaki, Jason W Locasale, Norbert Perrimon, David M Sabatini
Sestrin mediates detection of and adaptation to low-leucine diets in Drosophila. Nature 608 (7921) (2022)
Chengheng Liao, Cherise Ryan Glodowski, Cheng Fan, Juan Liu, Kevin R Mott, Akash Kaushik, Hieu Vu, Jason W Locasale, Samuel K McBrayer, Ralph J DeBerardinis, Charles M Perou, Yang Zhang
Integrated Metabolic Profiling and Transcriptional Analysis Reveals Therapeutic Modalities for Targeting Rapidly Proliferating Breast Cancers. Cancer research 82 (4) (2022)
Jason W Locasale
Diet and Exercise in Cancer Metabolism. Cancer discovery 12 (10) (2022)
Giusy Di Conza, Chin-Hsien Tsai, Hector Gallart-Ayala, Yi-Ru Yu, Fabien Franco, Lea Zaffalon, Xin Xie, Xiaoyun Li, Zhengtao Xiao, Lydia N Raines, Maryline Falquet, Antoine Jalil, Jason W Locasale, Piergiorgio Percipalle, David Masson, Stanley Ching-Cheng Huang, Fabio Martinon, Julijana Ivanisevic, Ping-Chih Ho
Tumor-induced reshuffling of lipid composition on the endoplasmic reticulum membrane sustains macrophage survival and pro-tumorigenic activity. Nature immunology 22 (11) (2021)
Inah Hwang, Hiroki Uchida, Ziwei Dai, Fei Li, Teresa Sanchez, Jason W Locasale, Lewis C Cantley, Hongwu Zheng, Jihye Paik
Cellular stress signaling activates type-I IFN response through FOXO3-regulated lamin posttranslational modification. Nature communications 12 (1) (2021)
Diana C Contreras Healey, Jacqueline Y Cephus, Sierra M Barone, Nowrin U Chowdhury, Debolanle O Dahunsi, Matthew Z Madden, Xiang Ye, Xuemei Yu, Kellen Olszewski, Kirsten Young, Valerie A Gerriets, Peter J Siska, Ryszard Dworski, Jonathan Hemler, Jason W Locasale, Masha V Poyurovsky, R Stokes Peebles, Jonathan M Irish, Dawn C Newcomb, Jeffrey C Rathmell
Targeting In Vivo Metabolic Vulnerabilities of Th2 and Th17 Cells Reduces Airway Inflammation. Journal of immunology (Baltimore, Md. : 1950) 206 (6) (2021)
Ziwei Dai, Vijyendra Ramesh, Jason W Locasale
The evolving metabolic landscape of chromatin biology and epigenetics. Nature reviews. Genetics 21 (12) (2020)
Philipp Gut, Sanna Matilainen, Jesse G Meyer, Pieti Pällijeff, Joy Richard, Christopher J Carroll, Liliya Euro, Christopher B Jackson, Pirjo Isohanni, Berge A Minassian, Reem A Alkhater, Elsebet Østergaard, Gabriele Civiletto, Alice Parisi, Jonathan Thevenet, Matthew J Rardin, Wenjuan He, Yuya Nishida, John C Newman, Xiaojing Liu, Stefan Christen, Sofia Moco, Jason W Locasale, Birgit Schilling, Anu Suomalainen, Eric Verdin
SUCLA2 mutations cause global protein succinylation contributing to the pathomechanism of a hereditary mitochondrial disease. Nature communications 11 (1) (2020)
Douglas B Fox, Nina Marie G Garcia, Brock J McKinney, Ryan Lupo, Laura C Noteware, Rachel Newcomb, Juan Liu, Jason W Locasale, Matthew D Hirschey, James V Alvarez
NRF2 activation promotes the recurrence of dormant tumour cells through regulation of redox and nucleotide metabolism. Nature metabolism 2 (4) (2020)
Chengheng Liao, Yang Zhang, Cheng Fan, Laura E Herring, Juan Liu, Jason W Locasale, Mamoru Takada, Jin Zhou, Giada Zurlo, Lianxin Hu, Jeremy M Simon, Travis S Ptacek, Victor G Andrianov, Einars Loza, Yan Peng, Huanghe Yang, Charles M Perou
Identification of BBOX1 as a Therapeutic Target in Triple-Negative Breast Cancer. Cancer discovery 10 (11) (2020)
Zhengtao Xiao, Jason W Locasale, Ziwei Dai
Metabolism in the tumor microenvironment: insights from single-cell analysis. Oncoimmunology 9 (1) (2020)
Qing Xu, Yuanyuan Li, Xia Gao, Kai Kang, Jason G Williams, Lingfeng Tong, Juan Liu, Ming Ji, Leesa J Deterding, Xuemei Tong, Jason W Locasale, Leping Li, Igor Shats, Xiaoling Li
HNF4α regulates sulfur amino acid metabolism and confers sensitivity to methionine restriction in liver cancer. Nature communications 11 (1) (2020)
Garrett J Brinkley, Hyeyoung Nam, Eunhee Shim, Richard Kirkman, Anirban Kundu, Suman Karki, Yasaman Heidarian, Jason M Tennessen, Juan Liu, Jason W Locasale, Tao Guo, Shi Wei, Jennifer Gordetsky, Teresa L Johnson-Pais, Devin Absher, Dinesh Rakheja, Anil K Challa, Sunil Sudarshan
Teleological role of L-2-hydroxyglutarate dehydrogenase in the kidney. Disease models & mechanisms 13 (11) (2020)
Kevin H Lin, Justine C Rutter, Abigail Xie, Bryann Pardieu, Emily T Winn, Reinaldo Dal Bello, Antoine Forget, Raphael Itzykson, Yeong-Ran Ahn, Ziwei Dai, Raiyan T Sobhan, Grace R Anderson, Katherine R Singleton, Amy E Decker, Peter S Winter, Jason W Locasale, Lorin Crawford, Alexandre Puissant, Kris C Wood
Using antagonistic pleiotropy to design a chemotherapy-induced evolutionary trap to target drug resistance in cancer. Nature genetics 52 (4) (2020)
Ryan T Davis, Kerrigan Blake, Dennis Ma, Mari B Ishak Gabra, Grace A Hernandez, Anh T Phung, Ying Yang, Dustin Maurer, Austin E Y T Lefebvre, Hamad Alshetaiwi, Zhengtao Xiao, Juan Liu, Jason W Locasale, Michelle A Digman, Eric Mjolsness, Mei Kong, Zena Werb, Devon A Lawson
Transcriptional diversity and bioenergetic shift in human breast cancer metastasis revealed by single-cell RNA sequencing. Nature cell biology 22 (3) (2020)
Geneviève Deblois, Seyed Ali Madani Tonekaboni, Giacomo Grillo, Constanza Martinez, Yunchi Ingrid Kao, Felicia Tai, Ilias Ettayebi, Anne-Marie Fortier, Paul Savage, Alexandra N Fedor, Xiaojing Liu, Paul Guilhamon, Evelyne Lima-Fernandes, Alex Murison, Hellen Kuasne, Wail Ba-Alawi, David W Cescon, Cheryl H Arrowsmith, Daniel D De Carvalho, Benjamin Haibe-Kains, Jason W Locasale, Morag Park, Mathieu Lupien
Epigenetic Switch-Induced Viral Mimicry Evasion in Chemotherapy-Resistant Breast Cancer. Cancer discovery 10 (9) (2020)
Yi-Ru Yu, Hana Imrichova, Haiping Wang, Tung Chao, Zhengtao Xiao, Min Gao, Marcela Rincon-Restrepo, Fabien Franco, Raphael Genolet, Wan-Chen Cheng, Camilla Jandus, Sergio A Quezada, Yi-Fan Jiang, Jason W Locasale, Alfred Zippelius, Pu-Ste Liu, Li Tang, Christoph Bock, Nicola Vannini, Ping-Chih Ho
Disturbed mitochondrial dynamics in CD8+ TILs reinforce T cell exhaustion. Nature immunology 21 (12) (2020)
Lelisa F Gemta, Peter J Siska, Marin E Nelson, Xia Gao, Xiaojing Liu, Jason W Locasale, Hideo Yagita, Craig L Slingluff, Kyle L Hoehn, Jeffrey C Rathmell, Timothy N J Bullock
Impaired enolase 1 glycolytic activity restrains effector functions of tumor-infiltrating CD8+ T cells. Science immunology 4 (31) (2020)
Vijyendra Ramesh, Jason W Locasale
A reactive metabolite as an immune suppressant. Nature immunology 21 (5) (2020)
Suman Kumar Vodnala, Robert Eil, Rigel J Kishton, Madhusudhanan Sukumar, Tori N Yamamoto, Ngoc-Han Ha, Ping-Hsien Lee, Min Hwa Shin, Shashank J Patel, Zhiya Yu, Douglas C Palmer, Michael J Kruhlak, Xiaojing Liu, Jason W Locasale, Jing Huang, Rahul Roychoudhuri, Toren Finkel, Christopher A Klebanoff, Nicholas P Restifo
T cell stemness and dysfunction in tumors are triggered by a common mechanism. Science (New York, N.Y.) 363 (6434) (2019)
Alex J Freemerman, Liyang Zhao, Ajeeth K Pingili, Bin Teng, Alyssa J Cozzo, Ashley M Fuller, Amy R Johnson, J Justin Milner, Maili F Lim, Joseph A Galanko, Melinda A Beck, James E Bear, Jeremy D Rotty, Lavanya Bezavada, Heather S Smallwood, Michelle A Puchowicz, Juan Liu, Jason W Locasale, Douglas P Lee, Brian J Bennett, E Dale Abel, Jeff C Rathmell, Liza Makowski
Myeloid Slc2a1-Deficient Murine Model Revealed Macrophage Activation and Metabolic Phenotype Are Fueled by GLUT1. Journal of immunology (Baltimore, Md. : 1950) 202 (4) (2019)
Sydney M Sanderson, Peter G Mikhael, Vijyendra Ramesh, Ziwei Dai, Jason W Locasale
Nutrient availability shapes methionine metabolism in p16/MTAP-deleted cells. Science advances 5 (6) (2019)
Peter C Hart, Tatsuyuki Chiyoda, Xiaojing Liu, Melanie Weigert, Marion Curtis, Chun-Yi Chiang, Rachel Loth, Ricardo Lastra, Stephanie M McGregor, Jason W Locasale, Ernst Lengyel, Iris L Romero
SPHK1 Is a Novel Target of Metformin in Ovarian Cancer. Molecular cancer research : MCR 17 (4) (2019)
Giada Zurlo, Xijuan Liu, Mamoru Takada, Cheng Fan, Jeremy M Simon, Travis S Ptacek, Javier Rodriguez, Alex von Kriegsheim, Juan Liu, Jason W Locasale, Adam Robinson, Jing Zhang, Jessica M Holler, Baek Kim, Marie Zikánová, Jörgen Bierau, Ling Xie, Xian Chen, Mingjie Li, Charles M Perou, Yang Zhang
Prolyl hydroxylase substrate adenylosuccinate lyase is an oncogenic driver in triple negative breast cancer. Nature communications 10 (1) (2019)
Sydney M Sanderson, Xia Gao, Ziwei Dai, Jason W Locasale
Methionine metabolism in health and cancer: a nexus of diet and precision medicine. Nature reviews. Cancer 19 (11) (2019)
P Kent Langston, Aya Nambu, Jonathan Jung, Munehiko Shibata, H Ibrahim Aksoylar, Jiahui Lei, Peining Xu, Mary T Doan, Helen Jiang, Michael R MacArthur, Xia Gao, Yong Kong, Edward T Chouchani, Jason W Locasale, Nathaniel W Snyder, Tiffany Horng
Glycerol phosphate shuttle enzyme GPD2 regulates macrophage inflammatory responses. Nature immunology 20 (9) (2019)
Ying Yang, Mari B Ishak Gabra, Eric A Hanse, Xazmin H Lowman, Thai Q Tran, Haiqing Li, Neta Milman, Juan Liu, Michael A Reid, Jason W Locasale, Ziv Gil, Mei Kong
MiR-135 suppresses glycolysis and promotes pancreatic cancer cell adaptation to metabolic stress by targeting phosphofructokinase-1. Nature communications 10 (1) (2019)
Cybelle Tabilas, Jocelyn Wang, Xiaojing Liu, Jason W Locasale, Norah L Smith, Brian D Rudd
Cutting Edge: Elevated Glycolytic Metabolism Limits the Formation of Memory CD8+ T Cells in Early Life. Journal of immunology (Baltimore, Md. : 1950) 203 (10) (2019)
Zhengtao Xiao, Ziwei Dai, Jason W Locasale
Metabolic landscape of the tumor microenvironment at single cell resolution. Nature communications 10 (1) (2019)
Linda V Sinclair, Andrew J M Howden, Alejandro J Brenes, Laura Spinelli, Jens L Hukelmann, Andrew N Macintyre, Xiaojing Liu, Sarah Thomson, Peter M Taylor, Jeffrey C Rathmell, Jason W Locasale, Angus I Lamond, Doreen A Cantrell
Antigen receptor control of methionine metabolism in T cells. eLife 8 (2019)
Jasmine L May, Fotini M Kouri, Lisa A Hurley, Juan Liu, Serena Tommasini-Ghelfi, Yanrong Ji, Peng Gao, Andrea E Calvert, Andrew Lee, Navdeep S Chandel, Ramana V Davuluri, Craig M Horbinski, Jason W Locasale, Alexander H Stegh
IDH3α regulates one-carbon metabolism in glioblastoma. Science advances 5 (1) (2019)
Matthew E Bechard, Anna E Word, Amanda V Tran, Xiaojing Liu, Jason W Locasale, Oliver G McDonald
Pentose conversions support the tumorigenesis of pancreatic cancer distant metastases. Oncogene 37 (38) (2018)
Ziwei Dai, Samantha J Mentch, Xia Gao, Sailendra N Nichenametla, Jason W Locasale
Methionine metabolism influences genomic architecture and gene expression through H3K4me3 peak width. Nature communications 9 (1) (2018)
Michael A Reid, Annamarie E Allen, Shiyu Liu, Maria V Liberti, Pei Liu, Xiaojing Liu, Ziwei Dai, Xia Gao, Qian Wang, Ying Liu, Luhua Lai, Jason W Locasale
Serine synthesis through PHGDH coordinates nucleotide levels by maintaining central carbon metabolism. Nature communications 9 (1) (2018)
Ziwei Dai, Jason W Locasale
Thermodynamic constraints on the regulation of metabolic fluxes. The Journal of biological chemistry 293 (51) (2018)
Wei Yan, Xiwei Wu, Weiying Zhou, Miranda Y Fong, Minghui Cao, Juan Liu, Xiaojing Liu, Chih-Hong Chen, Oluwole Fadare, Donald P Pizzo, Jiawen Wu, Liang Liu, Xuxiang Liu, Andrew R Chin, Xiubao Ren, Yuan Chen, Jason W Locasale, Shizhen Emily Wang
Cancer-cell-secreted exosomal miR-105 promotes tumour growth through the MYC-dependent metabolic reprogramming of stromal cells. Nature cell biology 20 (5) (2018)
Nicole M Chapman, Hu Zeng, Thanh-Long M Nguyen, Yanyan Wang, Peter Vogel, Yogesh Dhungana, Xiaojing Liu, Geoffrey A Neale, Jason W Locasale, Hongbo Chi
mTOR coordinates transcriptional programs and mitochondrial metabolism of activated Treg subsets to protect tissue homeostasis. Nature communications 9 (1) (2018)
Oliver A Stone, Mohamed A El-Brolosy, Kerstin Wilhelm, Xiaojing Liu, Ana M Romão, Elisabetta Grillo, Jason Kuan Han Lai, Stefan Günther, Sylvia Jeratsch, Carsten Kuenne, I-Ching Lee, Thomas Braun, Massimo M Santoro, Jason W Locasale, Michael Potente, Didier Y R Stainier
Loss of pyruvate kinase M2 limits growth and triggers innate immune signaling in endothelial cells. Nature communications 9 (1) (2018)
Mahya Mehrmohamadi, Seong Ho Jeong, Jason W Locasale
Molecular features that predict the response to antimetabolite chemotherapies. Cancer & metabolism 5 (2017)
Michael A Reid, Ziwei Dai, Jason W Locasale
The impact of cellular metabolism on chromatin dynamics and epigenetics. Nature cell biology 19 (11) (2017)
Xiuxing Wang, Kailin Yang, Qi Xie, Qiulian Wu, Stephen C Mack, Yu Shi, Leo J Y Kim, Briana C Prager, William A Flavahan, Xiaojing Liu, Meromit Singer, Christopher G Hubert, Tyler E Miller, Wenchao Zhou, Zhi Huang, Xiaoguang Fang, Aviv Regev, Mario L Suvà, Tae Hyun Hwang, Jason W Locasale, Shideng Bao, Jeremy N Rich
Purine synthesis promotes maintenance of brain tumor initiating cells in glioma. Nature neuroscience 20 (5) (2017)
Shuang Tang, Yi Fang, Gang Huang, Xiaojiang Xu, Elizabeth Padilla-Banks, Wei Fan, Qing Xu, Sydney M Sanderson, Julie F Foley, Scotty Dowdy, Michael W McBurney, David C Fargo, Carmen J Williams, Jason W Locasale, Ziqiang Guan, Xiaoling Li
Methionine metabolism is essential for SIRT1-regulated mouse embryonic stem cell maintenance and embryonic development. The EMBO journal 36 (21) (2017)
Oliver G McDonald, Xin Li, Tyler Saunders, Rakel Tryggvadottir, Samantha J Mentch, Marc O Warmoes, Anna E Word, Alessandro Carrer, Tal H Salz, Sonoko Natsume, Kimberly M Stauffer, Alvin Makohon-Moore, Yi Zhong, Hao Wu, Kathryn E Wellen, Jason W Locasale, Christine A Iacobuzio-Donahue, Andrew P Feinberg
Epigenomic reprogramming during pancreatic cancer progression links anabolic glucose metabolism to distant metastasis. Nature genetics 49 (3) (2017)
Ziwei Dai, Jason W Locasale
Metabolic pattern formation in the tumor microenvironment. Molecular systems biology 13 (2) (2017)
Maria V Liberti, Jason W Locasale
Metabolism: A new layer of glycolysis. Nature chemical biology 12 (8) (2017)
Sushabhan Sadhukhan, Xiaojing Liu, Dongryeol Ryu, Ornella D Nelson, John A Stupinski, Zhi Li, Wei Chen, Sheng Zhang, Robert S Weiss, Jason W Locasale, Johan Auwerx, Hening Lin
Metabolomics-assisted proteomics identifies succinylation and SIRT5 as important regulators of cardiac function. Proceedings of the National Academy of Sciences of the United States of America 113 (16) (2016)
Min Pan, Michael A Reid, Xazmin H Lowman, Rajan P Kulkarni, Thai Q Tran, Xiaojing Liu, Ying Yang, Jenny E Hernandez-Davies, Kimberly K Rosales, Haiqing Li, Willy Hugo, Chunying Song, Xiangdong Xu, Dustin E Schones, David K Ann, Viviana Gradinaru, Roger S Lo, Jason W Locasale, Mei Kong
Regional glutamine deficiency in tumours promotes dedifferentiation through inhibition of histone demethylation. Nature cell biology 18 (10) (2016)
Valerie A Gerriets, Rigel J Kishton, Marc O Johnson, Sivan Cohen, Peter J Siska, Amanda G Nichols, Marc O Warmoes, Aguirre A de Cubas, Nancie J MacIver, Jason W Locasale, Laurence A Turka, Andrew D Wells, Jeffrey C Rathmell
Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression. Nature immunology 17 (12) (2016)
Ahmad A Cluntun, He Huang, Lunzhi Dai, Xiaojing Liu, Yingming Zhao, Jason W Locasale
The rate of glycolysis quantitatively mediates specific histone acetylation sites. Cancer & metabolism 3 (2015)
Alexander A Shestov, Xiaojing Liu, Zheng Ser, Ahmad A Cluntun, Yin P Hung, Lei Huang, Dongsung Kim, Anne Le, Gary Yellen, John G Albeck, Jason W Locasale
Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step. eLife 3 (2014)

Jason W Locasale

Publication Activity (10 Years)

Top Topics

Top Venues