Maternal pre-pregnancy body mass index is associated with newborn offspring hypothalamic mean diffusivity: a prospective dual-cohort study.
Jerod M RasmussenJetro J TuulariSaara NolviPaul M ThompsonHarri MerisaariMaria LavoniusLinnea KarlssonSonja EntringerPathik D WadhwaHasse KarlssonClaudia BussPublished in: BMC medicine (2023)
These findings translate the preclinically established association between maternal obesity during pregnancy and offspring hypothalamic microstructure to the human context. In addition to further replication/generalization, future efforts to identify biological mediators of the association between maternal obesity and fetal HTH development are warranted to develop targeted strategies for the primary prevention of childhood obesity.
Keyphrases
- birth weight
- weight gain
- pregnancy outcomes
- body mass index
- insulin resistance
- metabolic syndrome
- high fat diet
- weight loss
- type diabetes
- endothelial cells
- high fat diet induced
- pregnant women
- physical activity
- white matter
- preterm birth
- quality improvement
- adipose tissue
- multiple sclerosis
- drug delivery
- induced pluripotent stem cells
- pluripotent stem cells