l-Carnitine relieves cachexia-related skeletal muscle fibrosis by inducing deltex E3 ubiquitin ligase 3L to negatively regulate the Runx2/COL1A1 axis.

Zongliang LuLi WangZhenyu HuoNa LiNing TongFeifei ChongJie LiuYaowen ZhangHong-Xia Xu

Published in: Journal of cachexia, sarcopenia and muscle (2024)

This study revealed a previously unrecognized link between Runx2 and DTX3L in SMF and demonstrated that l-carnitine exerted a significant therapeutic impact on cancer cachexia-associated SMF, potentially through the upregulation of DTX3L.

Keyphrases

skeletal muscle
transcription factor
papillary thyroid
insulin resistance
poor prognosis
squamous cell carcinoma
single cell
signaling pathway
adipose tissue
type diabetes
metabolic syndrome