Complex Repolarization Dynamics in Ex-Vivo Human Ventricles are Independent of the Restitution Properties.
Shahriar IravanianIlija UzelacAnand D ShahMikael J ToyeMichael S LloydMichael A BurkeMani A DaneshmandTamer S AttiaJ David VegaMikhael F El-ChamiFaisal M MerchantElizabeth M CherryNeal Kumar BhatiaFlavio H FentonPublished in: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology (2023)
We present evidence of complex higher-order periodicities and the co-existence of such regions with stable non-chaotic areas in ex-vivo human hearts. We infer that the oscillation of the calcium cycling machinery is the primary mechanism of higher-order dynamics. These higher-order regions may act as niduses of instability and may provide targets for substrate-based ablation of VF.