A Pilot Randomized Clinical Trial of Intranasal Oxytocin to Promote Weight Loss in Individuals With Hypothalamic Obesity.
Shana E McCormackZi WangKristin L WadeAnna DedioNicolette CilentiJulia CrowleyFranziska PlessowVaneeta BambaJeffrey D RoizenYaoguang JiangJack StylliArjun RamakrishnanMichael L PlattKaruna ShekdarMichael J FisherVictoria L VetterMatthew HockingRui XiaoElizabeth A LawsonPublished in: Journal of the Endocrine Society (2023)
In this pilot study in hypothalamic obesity, we did not detect a significant impact of intranasal OXT on body weight. OXT was well-tolerated, so future larger studies could examine different dosing, combination therapies, and potential psychosocial benefits.
Keyphrases
- weight loss
- body weight
- bariatric surgery
- clinical trial
- roux en y gastric bypass
- insulin resistance
- metabolic syndrome
- gastric bypass
- weight gain
- high fat diet induced
- type diabetes
- phase ii
- adipose tissue
- current status
- mental health
- randomized controlled trial
- study protocol
- glycemic control
- risk assessment
- case control