Effects of apolipoprotein E polymorphism on cerebral oxygen saturation, cerebral perfusion, and early prognosis after traumatic brain injury.
Xun LinQilin LiXiaochuan SunQuanhong ShiWei DanYan ZhanBo DengYulong XiaYanfeng XieLi JiangPublished in: Annals of clinical and translational neurology (2023)
Both cerebral perfusion and cerebral oxygen were significantly impaired after TBI, and low cerebral perfusion and hypoxia were related to poor prognosis of patients with TBI. Compared with APOE ε4 non-carriers, APOE ε4 carriers not only had poorer cerebral perfusion and cerebral oxygen metabolism but also worse prognosis in the early stages of TBI. Furthermore, a negative correlation was observed between the rSCO2 and MTT levels. In addition, both CT perfusion scanning (CTP) and NIRS are reliable for monitoring the condition of patients with TBI in the neurological intensive care unit (NICU).
Keyphrases
- subarachnoid hemorrhage
- traumatic brain injury
- poor prognosis
- contrast enhanced
- intensive care unit
- cerebral ischemia
- long non coding rna
- severe traumatic brain injury
- cognitive decline
- magnetic resonance imaging
- magnetic resonance
- high fat diet
- cerebral blood flow
- image quality
- high resolution
- extracorporeal membrane oxygenation
- mild cognitive impairment
- drug induced