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Responsible RAD: Striving for best practices in population genomic studies of adaptation.

David B LowrySean HobanJoanna L KelleyKatie E LotterhosLaura K ReedMichael F AntolinAndrew Storfer
Published in: Molecular ecology resources (2019)
Two recent articles were written in response to our paper "Breaking RAD: An evaluation of the utility of restriction site associated DNA sequencing scans of adaptation." While we agree with some of the comments made by the authors of these two response papers, we still believe caution should be employed in RADseq studies that aim to detect loci that contribute to adaptation. In this rebuttal, we evaluate the key points made in these papers, attempt to identify a middle ground and make suggestions for responsibly conducting future studies to understand the genomewide mechanisms of adaptation.
Keyphrases
  • case control
  • dna damage
  • dna repair
  • healthcare
  • primary care
  • computed tomography
  • genome wide
  • magnetic resonance imaging
  • current status
  • oxidative stress
  • copy number
  • cell free
  • dna methylation
  • genome wide association