The genetic and evolutionary basis of gene expression variation in East Africans.

Derek E KellyShweta RamdasRong MaRenata A Rawlings-GossGregory R GrantAlessia RanciaroJibril B HirboWilliam BeggsMeredith YeagerStephen ChanockThomas B NyamboSabah A OmarDawit WoldemeskelGurja BelayHongzhe LiChristopher D BrownSarah A Tishkoff

Published in: Genome biology (2023)

Extending QTL mapping studies beyond European ancestry, particularly to diverse indigenous populations, is vital for a complete understanding of the genetic architecture of human traits and can reveal novel functional variation underlying human traits and disease.

Keyphrases

genome wide
gene expression
endothelial cells
dna methylation
induced pluripotent stem cells
copy number
pluripotent stem cells
high resolution
single cell
mass spectrometry
genetic diversity