Monomer-Promoting Asymmetric Kinetic Resolution-Alternating Copolymerization To Afford AAB-Type Copolyesters.

Living copolymerization of mixed monomers can enrich the diversity of copolymer materials with well-defined performance via controlling both monomers and stereosequences. However, periodic sequence-controlled living copolymerization of same-type monomers with more than two components in synthetic polymer science remains a challenge. In this work, a new method of monomer-promoting asymmetric kinetic resolution-alternating copolymerization can let a tricomponent mixture of l-lactide ( S,S -LA or l-LA) and two enantiomeric isomers of racemic tropic acid cyclic esters (tropicolactone) be polymerized into sequence-controlled -(A S A S B S ) n - type biodegradable copolyesters (the subscript S presents the configuration and A and B present lactic acid units and tropic acid units, respectively), and diblock copolymers of -(A S A S B S ) n - b -(A R A R B R ) n - can further be obtained upon addition of R,R -LA (d - LA). Compared to previous asymmetric kinetic resolutions of racemic chemicals via polymerization or organic reactions, no enantiopure catalyst/initiator is required in this system. After the resolution and alternating copolymerization of S,S -LA and rac -tropicolactone, the ee value of unreacted tropicolactone can reach 99.4%. The alternating probability between tropicolactone and lactide monomers is more than 96% in periodic sequence polymers of -(A S A S B S ) n -. The tetracomponent mixture of rac -lactide and rac -tropicolactone can be copolymerized into an alternating copolymer with a -((A S A S B S ) x - ran -(A R A R B R ) y ) n - structure, in which the stereoselective linkage probability of 95% after S , S -lactide ( R , R- lactide) followed by S -tropicolactone ( R -tropicolactone) keeps very high too.