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Generalizability of Blood Pressure Lowering Trials to Older Patients: Cross-Sectional Analysis.

James Peter SheppardMark LownJenni BurtEleanor TempleRebecca LoweHannah AshbyOliver ToddJulie AllenGary A FordRosalyn FraserCarl HeneghanF D Richard HobbsSue JowettPaul LittleJonathan MantJill MollisonRupert PayneMarney WilliamsLy-Mee YuRichard J McManus
Published in: Journal of the American Geriatrics Society (2020)
A possible unintended consequence of blood pressure criteria used by trials attempting to answer different primary questions is that for many older patients, no trial evidence exists to inform treatment decisions in routine practice. Caution should be exercised when applying results from existing trials to patients with frailty or multimorbidity.
Keyphrases
  • blood pressure
  • cross sectional
  • hypertensive patients
  • heart rate
  • primary care
  • healthcare
  • clinical trial
  • study protocol
  • clinical practice
  • metabolic syndrome
  • weight loss
  • open label
  • combination therapy