Synthesis of 3-aminoquinolines from α-imino rhodium carbenes and 2-aminobenzaldehydes.
Jiani LiJing FengTao ChenZe-Feng XuChuan-Ying LiPublished in: Organic & biomolecular chemistry (2023)
A facile and efficient synthetic method for 3-aminoquinolines has been reported. The straightforward process starts from easily available triazoles and 2-aminobenzaldehydes. Low catalyst loading and good functional group compatibility are the other two merits of this transformation. Easy decoration of the 3-aminoquinoline motifs enabled the convenient synthesis of bioactive molecules, demonstrating the potential of this protocol in organic synthesis.