Knockout of the Gsta4 Gene in Male Mice Leads to an Altered Pattern of Hepatic Protein Carbonylation and Enhanced Inflammation Following Chronic Consumption of an Ethanol Diet.
Colin T ShearnCasey F PulliamKim PedersenKyle MeredithKelly E MercerLaura M SabaDavid J OrlickyMartin J RonisDennis R PetersenPublished in: Alcoholism, clinical and experimental research (2018)
These data suggest long-term adaptation to EtOH in WT mice does not occur in GSTA4-/- mice. Products of lipid peroxidation appear to play a role in inflammatory responses due to EtOH. And EtOH effects on B-cell infiltration and autoimmune responses may be secondary to formation of carbonyl adducts.