Ceftolozane/Tazobactam Dosing Requirements Against Pseudomonas aeruginosa Bacteremia.
Jesús RuízAlejandra FerradaMiguel SalavertMónica GordonEsther VillarrealÁlvaro Castellanos-OrtegaPaula RamirezPublished in: Dose-response : a publication of International Hormesis Society (2020)
The standard doses of ceftolozane/tazobactam achieve an adequate fT >40%MIC value. However, doses of 2 g in extended infusion is necessary to reach a value of fT >100%MIC, especially in patients with an increased renal clearance and high levels of beta-lactamases expression.