The International Childhood Cancer Cohort Consortium (I4C): A research platform of prospective cohorts for studying the aetiology of childhood cancers.
Gabriella TikellisTerence DwyerOra PaltielGary S PhillipsStanley LemeshowJean GoldingKate NorthstoneAndy BoydSjurdur OlsenAkram GhantousZdenko HercegMary H WardSiri E HåbergPer MagnusJørn OlsenMarin StrömSomdat MahabirRena R JonesAnne-Louise PonsonbyJacqueline ClavelMarie Aline CharlesEdwin TrevathanZhengmin Min QianMilena M MauleXiu QiuYun-Chul HongSilvia BrandaliseEve RomanMelissa WakeJian-Rong HeMartha S Linetnull nullPublished in: Paediatric and perinatal epidemiology (2018)
The I4C is the first cohort consortium to have published findings on paediatric cancer using harmonised variables across six pregnancy/birth cohorts. Projected increases in sample size, expanding sources of exposure data (eg, linkages to environmental and administrative databases), incorporation of biological measures to clarify exposures and underlying molecular mechanisms and forthcoming joint efforts to complement case-control studies offer the potential for breakthroughs in paediatric cancer aetiologic research.
Keyphrases
- childhood cancer
- case control
- young adults
- papillary thyroid
- intensive care unit
- emergency department
- squamous cell
- big data
- human health
- high throughput
- climate change
- lymph node metastasis
- squamous cell carcinoma
- risk assessment
- drinking water
- randomized controlled trial
- pregnant women
- preterm birth
- early life
- artificial intelligence
- single cell
- life cycle