20-year depressive symptoms, dementia, and structural neuropathology in older women.
Andrew John PetkusXinhui WangDiana YounanLauren E SalminenSusan M ResnickStephen R RappMark A EspelandMargaret GatzKeith F WidamanRamon CasanovaHelena ChuiRyan T BarnardSarah A GaussoinJoseph S GoveasKathleen M HaydenVictor W HendersonBonnie C SachsSantiago SaldanaAladdin H ShadyabSally A ShumakerJiu-Chiuan ChenPublished in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)
There are heterogeneous profiles of depressive symptoms and dementia risk. Common neuropathological factors may contribute to both depression and dementia. Highlights The progression of depressive symptoms and concurrent dementia risk is heterogeneous. Emerging depressive symptoms may be a prodromal symptom of dementia. Cerebrovascular disease and AD are potentially shared neuropathological factors.