Maternal Malaria and Malnutrition (M3) initiative, a pooled birth cohort of 13 pregnancy studies in Africa and the Western Pacific.
Holger W UngerJordan E CatesJulie GutmanValerie BriandNadine FievetInnocent ValeaHalidou TintoUmberto d'AlessandroSarah H LandisSeth Adu-AfarwuahKathryn G DeweyFeiko Ter KuileStephanie DellicourPeter OumaLaurence SlutskerDianne J TerlouwSimon KariukiJohn AyisiBernard NahlenMeghna DesaiMwayi MadanitsaLinda Kalilani-PhiriPer AshornKenneth MaletaIvo MuellerDanielle StanisicChristentze SchmiegelowJohn LusinguDaniel WestreichAnna Maria van EijkSteven MeshnickStephen RogersonPublished in: BMJ open (2016)
This pooled birth cohort is the largest pregnancy data set to date to permit a more definite evaluation of the impact of plausible interactions between poor nutritional status and malaria infection in pregnant women on fetal growth and gestational length. Given the current comparative lack of large pregnancy cohorts in malaria-endemic settings, compilation of suitable pregnancy cohorts is likely to provide adequate statistical power to assess malaria-nutrition interactions, and could point towards settings where such interactions are most relevant. The M3 cohort may thus help to identify pregnant women at high risk of adverse outcomes who may benefit from tailored intensive antenatal care including nutritional supplements and alternative or intensified malaria prevention regimens, and the settings in which these interventions would be most effective.
Keyphrases
- pregnant women
- pregnancy outcomes
- plasmodium falciparum
- preterm birth
- healthcare
- quality improvement
- physical activity
- birth weight
- south africa
- randomized controlled trial
- gestational age
- weight gain
- clinical trial
- weight loss
- body mass index
- artificial intelligence
- study protocol
- machine learning
- health insurance
- phase iii
- data analysis