Granzyme B PET imaging of immune-mediated tumor killing as a tool for understanding immunotherapy response.

Thomas LaSalleEmily E AustinGrant RigneyEric Wehrenberg-KleeSarah NestiBenjamin M LarimerUmar Mahmood

Published in: Journal for immunotherapy of cancer (2021)

These results suggest that discrete tumor immune microenvironments can be identified in both responsive and non-responsive tumors and offers strategic targets for intervention to overcome checkpoint inhibitor resistance.

Keyphrases

pet imaging
cancer therapy
randomized controlled trial
dna damage
cell cycle
positron emission tomography
oxidative stress
computed tomography