Prevalence and Determinants of Peripheral Microvascular Endothelial Dysfunction in Rheumatoid Arthritis Patients: A Multicenter Cross-Sectional Study.
Gian Luca ErreMatteo PigaAnna Laura FedeleSilvia MuraAlessandra PirasMaria Luisa CadoniIgnazio CangemiMartina DessiGabriele Di SanteBarbara TolussoElisa GremeseAlberto CauliArduino Aleksander MangoniPier Sergio SabaCiriaco CarruGianfranco FerraccioliAlessandro MathieuGiuseppe PassiuPublished in: Mediators of inflammation (2018)
This study demonstrates for the first time a high prevalence of peripheral microvascular ED in patients with RA free of previous cardiovascular events that appear to be only partially driven by traditional cardiovascular risk factors. The association between ACPA negativity and ED warrants further exploration.