Sex differences in CGRP-induced vasodilation of human middle meningeal arteries but not human coronary arteries: implications for migraine.

Tessa de VriesDeirdre M BoucherieKayi Y ChanEloísa Rubio-BeltránAlejandro Labastida-RamírezSieneke LabruijereSaurabh GuptaAntoon van den BogaerdtArnaud VincentRuben DammersA H Jan DanserAntoinette MaassenVanDenBrink

Published in: Cephalalgia : an international journal of headache (2024)

Sex differences were observed for CGRP-induced relaxation of HMMA, but not HCA. These differences could arise from differential receptor expression in the vascular beds combined with the effect of sex hormones on CGRP and subsequent receptor desensitization.

Keyphrases

endothelial cells
high glucose
diabetic rats
induced pluripotent stem cells
pluripotent stem cells
coronary artery disease
coronary artery
drug induced
heart failure
oxidative stress
blood flow
atrial fibrillation
aortic valve