Targeted Therapy, Chemotherapy, Immunotherapy and Novel Treatment Options for Different Subtypes of Salivary Gland Cancer.
Sarina Katrin MüllerMarlen HaderleinSebastian LettmaierAbbas AgaimyFlorian HallerMarkus HechtRainer FietkauHeinrich IroKonstantinos MantsopoulosPublished in: Journal of clinical medicine (2022)
Surgical resection remains the first line treatment for salivary gland cancer (SGC). In the case of locally advanced disease, surgery is followed by adjuvant radiotherapy. Surgical resection should be favored in resectable locoregional recurrent disease as well, and even the complete resection of all distant oligometastases has clinical benefit for the patients. For inoperable and disseminated metastatic disease, a multitude of systemic therapies including chemotherapy, targeted therapy, and immunotherapy are available. In this review, the current therapeutic options for inoperable recurrent or metastatic SGCs are summarized. Systemic treatment can achieve prolonged progression-free and overall survival, while the overall prognosis remains poor. Current clinical trials include only a limited number of patients and mostly combine different histologic subtypes. Additionally, no randomized controlled trial comparing different therapeutic options has been performed. In the future, further studies with a larger patient cohort and ideally only one histologic subtype are needed in order to improve the outcome for SGC patients. However, this may be difficult to accomplish due to the rarity and diversity of the disease. Additionally, molecular analyses need to be performed routinely in order to individualize treatment and to go one step further towards precision medicine.
Keyphrases
- locally advanced
- end stage renal disease
- randomized controlled trial
- squamous cell carcinoma
- clinical trial
- newly diagnosed
- ejection fraction
- chronic kidney disease
- radiation therapy
- rectal cancer
- peritoneal dialysis
- small cell lung cancer
- neoadjuvant chemotherapy
- early stage
- prognostic factors
- papillary thyroid
- patient reported outcomes
- systematic review
- atrial fibrillation
- radiation induced
- combination therapy
- young adults
- coronary artery bypass
- patient reported
- lymph node metastasis
- current status