Serum cholesterol loading capacity on macrophages is regulated by seropositivity and C-reactive protein in rheumatoid arthritis patients.

Oxidized LDL can directly influence CLC in dual seropositive RA patients. Two additional and independent pathways-via anti-oxLDL IgG and PCSK9-may mediate the effects of oxPL-apoB100 on CLC depending on CRP and seropositivity status. If externally validated, these findings may have clinical implications for cardiovascular risk prevention.