International Consensus Definition of DNA Methylation Subgroups in Juvenile Myelomonocytic Leukemia.

Maximilian SchönungJulia MeyerPeter NoellkeAdam B OlshenMark HartmannNorihiro MurakamiManabu WakamatsuYusuke OkunoChristoph PlassMignon L LohCharlotte M NiemeyerHideki MuramatsuChristian FlothoElliot Stieglitz Daniel B Lipka

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)

This study provides an international consensus definition for DNA methylation subgroups in JMML. We developed and validated methods which will facilitate the design of risk-stratified clinical trials in JMML.

Keyphrases

dna methylation
clinical trial
genome wide
gene expression
clinical practice
acute myeloid leukemia
bone marrow
open label