Organocatalytic radical relay trifunctionalization of unactivated alkenes by a combination of cyano migration and alkylacylation.

The first N -heterocyclic carbene organocatalytic three-component radical relay trifunctionalization of unactivated alkenes through the combination of remote 1,4-cyano migration and alkylacylation was reported. This protocol features mild reaction conditions, readily available materials, excellent regioselectivity, and capability of late-stage functionalization.