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Organocatalytic radical relay trifunctionalization of unactivated alkenes by a combination of cyano migration and alkylacylation.

Jingyi WangYuchan WangJibin LiZexuan WeiJie FengDing Du
Published in: Chemical communications (Cambridge, England) (2023)
The first N -heterocyclic carbene organocatalytic three-component radical relay trifunctionalization of unactivated alkenes through the combination of remote 1,4-cyano migration and alkylacylation was reported. This protocol features mild reaction conditions, readily available materials, excellent regioselectivity, and capability of late-stage functionalization.
Keyphrases
  • randomized controlled trial