Early inflammatory changes in radiation-induced oral mucositis : Effect of pentoxifylline in a mouse model.

Sylvia GruberEva BozsakyEva RoitingerKaroline SchwarzMargret SchmidtWolfgang Dörr

Published in: Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] (2017)

Early inflammation, as indicated by the expression of the inflammatory markers TNFα, NF-κB, and IL-1β, is an essential component of early radiogenic oral mucositis. Pentoxifylline differentially modulated the expression of different inflammatory markers. The mucoprotective effect of pentoxifylline does not appear to be based on modulation of NF-κB-associated inflammation.

Keyphrases

radiation induced
oxidative stress
poor prognosis
radiation therapy
mouse model
signaling pathway
lps induced
rheumatoid arthritis
nuclear factor
pi k akt
binding protein
long non coding rna