MicroRNA-5010-5p ameliorates high-glucose induced inflammation in renal tubular epithelial cells by modulating the expression of PPP2R2D.
Sunghee ChoiMithun Kumer SarkerMi Ra YuHaekyung LeeSoon Hyo KwonJin Seok JeonHyunjin NohHyoungnae KimPublished in: BMJ open diabetes research & care (2024)
Our findings suggest that increased miR-5010-5p expression reduces high glucose-induced inflammatory responses in renal tubular epithelial cells via the regulation of the target gene, PPP2R2D, which modulates AMPK phosphorylation. Therefore, miR-5010-5p may be a promising therapeutic target for DKD.