Human monocytes subjected to ischaemia/reperfusion inhibit angiogenesis and wound healing in vitro.
Lars HummitzschMartin AlbrechtKarina ZittaKatharina HessKerstin ParczanyRené RuschJochen CremerMarkus SteinfathAssad HaneyaFred FaendrichRouven BerndPublished in: Cell proliferation (2020)
In summary, monocytes showed no significant change in cellular integrity and monocyte subtype after I/R. Functionally, monocytes might have a rather detrimental influence during the initial phase of I/R, suppressing endothelial cell migration and neoangiogenesis.
Keyphrases
- endothelial cells
- cell migration
- dendritic cells
- peripheral blood
- wound healing
- vascular endothelial growth factor
- acute myocardial infarction
- signaling pathway
- cerebral ischemia
- immune response
- acute ischemic stroke
- pluripotent stem cells
- heart failure
- brain injury
- blood brain barrier
- coronary artery disease
- percutaneous coronary intervention
- atrial fibrillation
- subarachnoid hemorrhage