NUF2 Expression in Cancer Tissues and Lymph Nodes Suggests Post-Surgery Recurrence of Non-Small Cell Lung Cancer.
Chika ShirakamiKoei IkedaHironori HinokumaWataru NishiYusuke ShinchiEri MatsubaraHironobu OsumiKosuke FujinoMakoto SuzukiPublished in: Diagnostics (Basel, Switzerland) (2024)
In non-small cell lung cancer (NSCLC) cases, detecting potential lymph node metastases is essential to determine the indications for sublobar resection or adjuvant therapy. NUF2 is a tumor-specific antigen that is highly expressed in lung cancer tissues. However, the significance of analyzing NUF2 expression in dissected lymph nodes has not yet been studied. Thus, we investigated the association between NUF2 expression in lung cancer tissues and dissected lymph nodes and early recurrence of NSCLC to determine its usefulness as a marker of lymph node micrometastasis. This retrospective study quantified NUF2 expression in the cancer tissues of 88 patients with NSCLC who underwent complete resection using real-time polymerase chain reaction and investigated its relationship with clinicopathological features and prognosis. We also quantified NUF2 RNA expression in mediastinal lymph nodes from 255 patients with pN0 NSCLC who underwent complete resection with lymph node dissection and analyzed its association with prognosis. NUF2 expression in primary tumors was correlated with lymph node metastasis and unfavorable outcomes in terms of poor recurrence-free and cancer-specific survival. In N0 NSCLC cases, high NUF2 expression in mediastinal lymph nodes indicated poor prognosis, especially in lymph node recurrence. NUF2 emerges as a promising marker for predicting lymph node metastatic recurrence, offering potential utility in guiding post-surgical adjuvant therapy for lung cancer or assisting in intraoperative decisions for sublobar resection.
Keyphrases
- lymph node
- poor prognosis
- sentinel lymph node
- small cell lung cancer
- neoadjuvant chemotherapy
- long non coding rna
- papillary thyroid
- lymph node metastasis
- gene expression
- squamous cell carcinoma
- free survival
- binding protein
- advanced non small cell lung cancer
- radiation therapy
- patients undergoing
- mass spectrometry
- early stage
- metabolic syndrome
- minimally invasive
- climate change
- risk assessment
- coronary artery disease
- brain metastases
- percutaneous coronary intervention
- insulin resistance
- weight loss
- prostate cancer
- young adults
- high speed
- glycemic control
- surgical site infection
- atomic force microscopy