Agomirs upregulating carboxypeptidase E expression rescue hippocampal neurogenesis and memory deficits in Alzheimer's disease.
Dongfang JiangHongmei LiuTingting LiSong ZhaoKeyan YangFuwen YaoBo ZhouHaiping FengSijia WangJiaqi ShenJinglan TangYu-Xin ZhangYun WangCaixia GuoTie-Shan TangPublished in: Translational neurodegeneration (2024)
CPE may regulate adult hippocampal neurogenesis via the CPE-BDNF-TrkB signaling pathway. This study supports the prospect of developing miRNA agomirs targeting CPE as biopharmaceuticals to counteract aging- and disease-related neurological decline in human brains.
Keyphrases
- cerebral ischemia
- signaling pathway
- endothelial cells
- poor prognosis
- traumatic brain injury
- subarachnoid hemorrhage
- blood brain barrier
- pi k akt
- neural stem cells
- epithelial mesenchymal transition
- working memory
- cancer therapy
- young adults
- drug delivery
- oxidative stress
- temporal lobe epilepsy
- cell proliferation
- endoplasmic reticulum stress
- drug induced