Differential and longitudinal immune gene patterns associated with reprogrammed microenvironment and viral mimicry in response to neoadjuvant radiotherapy in rectal cancer.

Anna C WilkinsElisa FontanaGift NyamundandaChanthirika RagulanYatish PatilDavid MansfieldJennifer KingstonFiona Errington-MaisDaniel BottomleyKatharina von LogaHannah ByePaul CarterEmma Tinkler-HundalAmir NoshirwaniJessica DownsMagnus DillonSandra DemariaDavid Sebag-MontefioreKevin HarringtonNick WestAlan MelcherAnguraj Sadanandam

Published in: Journal for immunotherapy of cancer (2021)

This study suggests potentially druggable immune targets in poor responders at baseline and indicates that tumors with a good RT/CRT response reprogrammed from immune "cold" towards an immunologically "hot" phenotype on treatment with radiotherapy.

Keyphrases

locally advanced
rectal cancer
early stage
radiation therapy
squamous cell carcinoma
stem cells
radiation induced
sars cov
lymph node
genome wide
copy number
cross sectional
gene expression
cardiac resynchronization therapy