Somatic mosaicism in patients with Fanconi anaemia: Proposal of alternative tissue for inconclusive diagnoses.

Camila Oliveira Pereira Daniela Vandresen Pillonetto Tamara Borgonovo Carmen Lúcia Kuniyoshi Rebelatto Miriam Lacerda BarbosaMaria Cristina FingerSamantha NicheleJoanna TrennepohlGisele Loth Carmem Maria Sales Bonfim

Published in: International journal of laboratory hematology (2022)

This study demonstrated the possibility of using BM-MSCs as an alternative tissue for cytogenetic and molecular investigation. Future tests using an intermediate DEB concentration may lead to an optimal protocol that could be non-toxic to cells but provides conclusive results.

Keyphrases

induced apoptosis
mesenchymal stem cells
randomized controlled trial
cell cycle arrest
current status
gene expression
cell proliferation
single molecule
umbilical cord
signaling pathway
iron deficiency