Effects of intestine-specific deletion of FGF15 on the development of fatty liver disease with vertical sleeve gastrectomy.

Monica D ChowKatherine OtersenAndrew WassefBo Kong Sowmya Yamarthy Daniel Rizzolo Ill Yang Brian T Buckley Alexander LuNaomi CrookMatthew LeeJudy GaoSareena NaganandMary F Stofan Laura E Armstrong Justin D Schumacher Rulaiha Taylor Zakiyah R Henry Veronia Basaly Zhenning Yang Min Zhang Mingxing HuangLeonid KaganLuigi BrunettiRagui SadekYi-Horng Lee Grace L Guo

Published in: Hepatology communications (2024)

FGF15 deficiency, the larger BA pool and higher levels of secondary BAs may increase energy expenditure in extrahepatic tissues, which may be responsible for improved metabolic functions following SGx.

Keyphrases

gene expression
replacement therapy
fatty acid