Vaccination is an important part of the fight against COVID-19 virus. A predictor of the proportion of people who will actually take a vaccination is the willingness to vaccinate among the population. Literature shows that vaccination willingness among people with lower socioeconomic status is lower than among other groups. In this contribution we describe to what extent this is also the case in the Netherlands and show how risk perception, trust in the effects and safety of the vaccine, and health literacy may be related to this. Finally, we highlight a number of intervention strategies that can make a positive contribution to vaccination willingness among lower educated groups.