Human papillomavirus vaccination in women undergoing excisional treatment for cervical intraepithelial neoplasia and subsequent risk of recurrence: A systematic review and meta-analysis.

Dina Overgaard Eriksen Pernille Tine Jensen Jeppe Bennekou Schroll Anne Hammer

Published in: Acta obstetricia et gynecologica Scandinavica (2022)

HPV vaccination post-treatment was associated with a significantly reduced risk of CIN2+ recurrence when using unadjusted estimates from observational studies and RCTs. We found no significant effect of HPV vaccination on risk of CIN2+ recurrence when using the outcome measure from observational studies with the least risk of bias. Large, well-designed randomized placebo-controlled trials are needed to determine whether post-treatment HPV vaccination should be recommended to all women undergoing excisional treatment for CIN.

Keyphrases

high grade
placebo controlled
clinical trial
double blind
polycystic ovary syndrome
randomized controlled trial
radiation therapy
open label
study protocol
skeletal muscle
rectal cancer