Effects of Omalizumab on Rhinovirus Infections, Illnesses, and Exacerbations of Asthma.
Ann EsquivelWilliam W BusseAgustin CalatroniAlkis G TogiasKristine G GrindleYury A BochkovRebecca S GruchallaMeyer KattanCarolyn M KercsmarG Khurana HersheyHaejin KimPetra LebeauAndrew H LiuStanley J SzeflerStephen J TeachJoseph B WestJeremy WildfireJaqueline A PongracicJames E GernPublished in: American journal of respiratory and critical care medicine (2017)
In children with allergic asthma, treatment with omalizumab decreased the duration of RV infections, viral shedding, and the risk of RV illnesses. These findings provide direct evidence that blocking IgE decreases susceptibility to RV infections and illness. Clinical trial registered with www.clinicaltrials.gov (NCT01430403).