CHI3L1 promotes proliferation and improves sensitivity to cetuximab in colon cancer cells by down-regulating p53.

Kaitai LiuMing JinShuang YeSenxiang Yan

Published in: Journal of clinical laboratory analysis (2019)

High levels of CHI3L1 are associated with poor prognosis and accelerate the proliferation of colon cancer cells and increase the sensitivity to cetuximab. Its mechanism of increasing the cell proliferation and sensitivity to cetuximab may be explained by down-regulating p53 expression and then, up-regulating the expression of EGFR.

Keyphrases

poor prognosis
long non coding rna
metastatic colorectal cancer
cell proliferation
locally advanced
signaling pathway
small cell lung cancer
wild type
tyrosine kinase
cell cycle